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Related Experiment Video

Updated: Jun 10, 2026

Caffeine Extraction, Enzymatic Activity and Gene Expression of Caffeine Synthase from Plant Cell Suspensions

Caffeine Extraction, Enzymatic Activity and Gene Expression of Caffeine Synthase from Plant Cell Suspensions

Published on: October 2, 2018

Coffee and endothelial function: a battle between caffeine and antioxidants?

S Buscemi¹, J A Batsis, G Arcoleo

¹Dipartimento di Medicina Interna, Malattie Cardiovascolari e NefroUrologiche, Facoltà di Medicina, University of Palermo, Palermo, Italy. silbus@tin.it

European Journal of Clinical Nutrition

|July 29, 2010

Summary

Caffeinated coffee may negatively impact cardiovascular health due to caffeine, while decaffeinated coffee shows antioxidant benefits for endothelial function. Further research is needed on long-term coffee consumption effects.

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Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells

Evaluation of Bioenergetic Function in Cerebral Vascular Endothelial Cells

Published on: November 19, 2016

Area of Science:

Cardiovascular Science
Nutritional Science
Biochemistry

Background:

Coffee consumption is widespread, yet its cardiovascular effects remain debated.
Previous research indicated differing acute impacts of caffeinated and decaffeinated espresso on endothelial function in healthy individuals.

Purpose of the Study:

To compare the antioxidant capacity of caffeinated and decaffeinated espresso.
To investigate the role of antioxidant activity versus caffeine in coffee's acute effects on endothelial function.

Main Methods:

Assessed antioxidant capacity using 2,2-diphenyl-1-picryl-hydrazyl (DPPH) 50% inhibition (I50 DPPH).
Measured endothelial function via flow-mediated dilation (FMD) of the brachial artery.

Main Results:

Caffeinated coffee exhibited a slightly higher antioxidant capacity (I50 DPPH: 1.13±0.02 μl) compared to decaffeinated espresso (I50 DPPH: 1.30±0.03 μl).
Antioxidant activity in decaffeinated coffee was linked to increased FMD, suggesting a protective effect.

Conclusions:

Caffeine may be responsible for adverse cardiovascular effects observed after caffeinated coffee intake.
The antioxidant properties of decaffeinated coffee appear beneficial for endothelial function.
Further clinical and epidemiological studies are necessary to elucidate the chronic health impacts of coffee consumption.