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Updated: Jun 10, 2026

12:05
Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
Published on: March 6, 2013
Synthesis of MUC1-lipopeptide chimeras
Brendan L Wilkinson1, Lara R Malins, Candy K Y Chun
1School of Chemistry, University of Sydney, NSW 2006, Australia.
Abstract:
An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the T(N) and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam(3)CysSer were synthesised in high yields using a fragment-based condensation strategy.

