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Updated: Jun 10, 2026

Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
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Evaluation of lymph node counts in primary retroperitoneal lymph node dissection.

R Houston Thompson1, Brett S Carver, George J Bosl

  • 1Department of Surgery-Urology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Cancer
|July 29, 2010
PubMed
Summary
This summary is machine-generated.

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Removing over 40 lymph nodes during retroperitoneal lymph node dissection (RPLND) for nonseminomatous germ cell tumors (NSGCTs) enhances diagnostic accuracy. This finding is crucial for quality assurance and assessing the thoroughness of lymph node removal in testicular cancer surgery.

Area of Science:

  • Urology
  • Surgical Oncology
  • Pathology

Background:

  • Lymph node counts are established quality metrics and prognostic indicators in various cancers.
  • Investigations into lymph node counts specifically for testicular cancer are limited.

Purpose of the Study:

  • To investigate factors associated with lymph node counts in testicular cancer patients.
  • To determine the relationship between lymph node counts and the detection of positive lymph nodes.
  • To evaluate the impact of lymph node count on diagnostic efficacy in retroperitoneal lymph node dissection (RPLND).

Main Methods:

  • Retrospective analysis of 255 patients undergoing primary RPLND for nonseminomatous germ cell tumors (NSGCTs) from 1999-2008.
  • Regression models were used to evaluate associations with lymph node counts and positive lymph nodes.

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  • Analysis included surgeon volume, clinical stage, year of surgery, and pathologist.

    • Main Results:

    • Median lymph node count was 38, increasing to 48 in the latter 5 years.
    • Higher lymph node counts were associated with high-volume surgeons, clinical stage, and more recent surgery year.
    • Clinical stage and total lymph node count significantly predicted positive lymph nodes.
    • The probability of positive lymph nodes increased with higher lymph node counts (e.g., 48% with >60 nodes).

    Conclusions:

    • Removing more than 40 lymph nodes during RPLND improves diagnostic efficacy for NSGCTs.
    • These findings are valuable for standardizing RPLND quality and comparing surgical outcomes in clinical trials.