Related Experiment Video

Updated: Jun 10, 2026

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

Microvascular dysfunction in hypertrophic cardiomyopathy evaluated by cardiac magnetic resonance and computed

Sergio Moral1, Leticia Fernandez-Friera, Javier Sanz

  • 1Dept. of Cardiology, Hospital Universitario Doctor Josep Trueta, Girona, Spain. moral.sergio@yahoo.es

Acta Cardiologica
|July 30, 2010
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) patients may experience chest pain due to microvascular dysfunction, leading to myocardial ischemia. Advanced imaging can identify risks associated with HCM progression and poor perfusion.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Medical Diagnostics

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex cardiac condition.
  • Chest pain evaluation is crucial for patients with HCM.
  • Understanding the mechanisms of ischemia in HCM is vital.

Observation:

  • A 36-year-old woman with HCM presented with chest pain.
  • Stress cardiac MRI revealed severe anteroseptal hypertrophy and ischemia post-adenosine.
  • Delayed enhancement imaging showed extensive hyperenhancement in hypertrophic segments.

Findings:

  • No significant coronary artery disease was detected by CT angiography.
  • Severe hypertrophy and ischemia were observed in the anteroseptal wall.
  • Extensive myocardial hyperenhancement correlated with hypertrophic segments.

Implications:

  • Microvascular dysfunction in HCM may predispose to myocardial ischemia and sudden death.
  • The relationship between hypertrophy extent and perfusion reserve requires further investigation.
  • Non-invasive imaging is valuable for risk stratification in HCM patients.

More Related Videos

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease12:15

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease

Published on: February 8, 2022

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...