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Related Experiment Video

Updated: Jun 10, 2026

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells

Published on: May 6, 2013

Genetically dependent ERBB3 expression modulates antigen presenting cell function and type 1 diabetes risk.

Hongjie Wang¹, Yulan Jin, M V Prasad Linga Reddy

¹Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia, United States of America.

|July 30, 2010

Summary

This summary is machine-generated.

Type 1 diabetes susceptibility is linked to the 12q13 region, with specific gene variants influencing ERBB3 expression. Higher ERBB3 levels in immune cells correlate with protection against type 1 diabetes.

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Area of Science:

Immunology
Genetics
Endocrinology

Background:

Type 1 diabetes (T1D) arises from genetic and environmental factors impacting the immune system.
Genome-wide association studies identified over 40 T1D susceptibility regions, but specific genes remain unclear.

Purpose of the Study:

Identify T1D susceptibility genes within the 12q13 region.
Investigate the functional role of these genes in T1D pathogenesis.

Main Methods:

Analyzed 19 single nucleotide polymorphisms (SNPs) in the 12q13 region in 1,434 T1D patients and 1,865 controls using TaqMan assay.
Assessed expression of six genes in peripheral blood mononuclear cells (PBMCs) from 192 T1D patients and 192 controls via real-time RT-PCR.
Examined ERBB3 protein expression on immune cells and its correlation with T cell proliferation.

Main Results:

Thirteen SNPs in the 12q13 region showed significant association with T1D (best p = 4x10(-11)).
SNP genotypes in this region determined ERBB3 mRNA levels in PBMCs, with protective genotypes linked to higher expression (p<10(-10)).
ERBB3 protein was found on dendritic cells and monocytes; protective genotypes correlated with increased ERBB3+ monocytes and dendritic cells, enhancing T cell proliferation.

Conclusions:

ERBB3 is a key susceptibility gene in the 12q13 region for Type 1 Diabetes.
ERBB3 expression levels significantly influence antigen-presenting cell (APC) function and T1D pathogenesis.