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Procainamide inhibits DNA methyltransferase in a human T cell line
L S Scheinbart1, M A Johnson, L A Gross
1Department of Internal Medicine, University of Michigan, Ann Arbor 48109-0531.
The Journal of Rheumatology
|April 1, 1991
Abstract:
Procainamide, a widely used antiarrythmic, causes DNA hypomethylation in the human T cell line Jurkat, but the mechanism is unknown. We report that procainamide inhibits the DNA methyltransferase catalyzed transfer of methyl groups from S-adenosylmethionine to DNA, but has no effect on other known regulators of DNA methylation. Our results suggest that procainamide could inhibit cellular DNA methylation by inhibiting DNA methyltransferase activity.