Related Experiment Video
Updated: Jun 10, 2026
08:31
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
[Towards cure for all children with acute lymphoblastic leukemia?]
André Baruchel1, Thierry Leblanc, Marie-Françoise Auclerc
1Hématologie Pédiatrique, Hôpital Robert Debré, 48 bld Serurier, 75019 Paris. andre.baruchel@rdb.aphp.fr
Bulletin De L'Academie Nationale De Medecine
|July 31, 2010
Summary
Childhood acute lymphoblastic leukemia (ALL) treatment has dramatically improved due to new drugs and research. Current efforts focus on tailoring therapies for low-risk and high-risk groups using advanced genomic analysis.
Area of Science:
- Pediatric Oncology
- Hematology
- Cancer Research
Context:
- Childhood acute lymphoblastic leukemia (ALL) outcomes have transformed from dismal to excellent over 40 years.
- Advances driven by specialized care units, improved supportive measures (transfusions, antibiotics, pain management), and coordinated research.
Purpose:
- To de-escalate treatment for defined low-risk pediatric ALL patient groups.
- To develop novel drugs and targeted therapies for high-risk pediatric ALL, informed by genomic data.
Summary:
- Significant progress in childhood ALL treatment is attributed to collaborative research and optimized drug utilization.
- Current research focuses on personalized medicine approaches, including genome-wide analysis for risk stratification.
Impact:
- Improved survival rates and quality of life for children with ALL.
- Establishes a model for advancing cancer treatment through integrated research and clinical practice.
Related Concept Videos
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
02:50Combination Therapies and Personalized Medicine
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:56Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
01:21Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...