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Updated: Jun 10, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
[Genetics of familial pituitary adenomas]
Albert Beckers1, Marie-Lise Jaffrain-Rea, Adrian E Daly
1Endocrinologie, CHU de Liège, Université de Liège, Domaine universitaire du Sart-Tilman, 4000 Liège, Belgique. albert.beckers@chu.ulg.ac.be
Abstract:
Pituitary adenomas were previously thought to be rare. However, a recent cross-sectional study conducted in Liège, Belgium, showed that clinically apparent pituitary adenomas were present in about 1 in 1000 inhabitants, which is 4 to 5 times the previously reported prevalence. Pituitary adenomas are generally sporadic, but some are associated with familial-isolated tumoral syndromes (mainly MEN1 and Carney complex). With the recent characterization of FIPA (Familial Isolated Pituitary Adenomas), familial pituitary adenomas are now thought to account for 5% to 8% of all pituitary tumors. New genetic mechanisms are being identified, improving our understanding of the complex manifestations and sometimes unpredictable outcome of pituitary adenomas.
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