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Related Experiment Video

Updated: Jun 10, 2026

Murine Fetal Echocardiography

Murine Fetal Echocardiography

Published on: February 15, 2013

Fetal MR imaging evidence of prolonged apparent diffusion coefficient decrease in fetal death.

T Tarui¹, O S Khwaja, J A Estroff

¹Departments of Neurology, Children’s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA. tomo.tarui@childrens.harvard.edu

AJNR. American Journal of Neuroradiology

|July 31, 2010

Summary

This summary is machine-generated.

Fetal brain imaging reveals persistent decreased diffusion weeks after fetal death. This finding indicates that diffusion changes cannot precisely date the timing of brain injury, impacting cause of death investigations.

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Area of Science:

Neurology
Radiology
Fetal Medicine

Background:

Fetal brain injury determination relies on accurate timing of insult.
Magnetic Resonance Imaging (MRI) is crucial for evaluating fetal brain development and pathology.

Observation:

Two cases of fetal death at 22 weeks gestational age (GA) were examined using MRI.
Cerebral imaging demonstrated restricted diffusion (bright diffusion-weighted imaging [DWI] and low apparent diffusion coefficient [ADC] values).
These imaging findings were observed 8 and 19 days post-mortem.

Findings:

Decreased water diffusion in the fetal brain can persist for weeks after death.
The presence of restricted diffusion does not allow for precise dating of the injury onset within a one-week window.

Implications:

This challenges the use of diffusion MRI parameters for determining the proximate cause of fetal brain injury.
Forensic and perinatal investigations require careful interpretation of diffusion imaging in post-mortem fetal cases.
Future research should focus on establishing reliable biomarkers for timing fetal brain injury.