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Updated: Jun 10, 2026

Isolation of Double Negative αβ T Cells from the Kidney
Published on: May 16, 2014
CD4+ T cells: a potential player in renal fibrosis
1Department of Nephrology and Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia. david.nikolic-paterson@med.monash.edu.au
Abstract:
T cells have a well-described role in renal injury, which leads to the secondary development of renal fibrosis. It has generally been assumed that this fibrotic response is an indirect consequence of T cell-mediated renal injury, rather than T cells' being directly involved in fibrosis. Tapmeier et al. now provide evidence that CD4(+) T cells promote interstitial fibrosis in the obstructed mouse kidney in a mechanism that appears to dissociate myofibroblast accumulation and matrix deposition.

