Related Experiment Video
Updated: Jun 10, 2026
08:25
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
[Allergic contact dermatitis for temporary "black henna" tattoos].
Ana I Sánchez Moya1, María E Gatica, Domingo García Almagro
1Servicio de Dermatología, Complejo Hospitalario ToledoBuenos Aires, España. anai.sanchezmoya@yahoo.es
Archivos Argentinos De Pediatria
|July 31, 2010
Summary
Temporary black henna tattoos, popular among children, pose risks. These tattoos, containing paraphenylenediamine (PPD), can cause severe allergic reactions and long-term skin issues, necessitating caution.
Area of Science:
- Dermatology
- Allergology
- Pediatric Health
Background:
- Temporary tattoos, particularly 'black henna', are increasingly popular among children.
- Black henna is not a natural product; it is derived from henna with added chemicals, notably paraphenylenediamine (PPD).
Observation:
- Paraphenylenediamine (PPD) is a known potent sensitizer, significantly increasing the risk of allergic contact dermatitis.
- Adverse events associated with black henna tattoos are on the rise in the pediatric population.
Findings:
- The study details a case of an eleven-year-old girl who developed allergic contact dermatitis from a black henna tattoo.
- Patch testing confirmed a positive reaction to PPD, identifying the causative agent.
Implications:
- Sensitization to PPD can lead to persistent local reactions and pigmentary changes.
- Individuals sensitized to PPD may experience adverse reactions to various everyday products containing this chemical.
- Healthcare providers and parents should be aware of the risks associated with temporary black henna tattoos to prevent adverse health outcomes in children.
Related Concept Videos
01:30Drug Toxicity: Allergic Reactions
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
01:29Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
01:19Hypersensitivity Reactions: Immune-Complex Reactions
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
01:30Allergic Reactions: Anaphylaxis
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
01:30Hypersensitivities
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...