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Abstract:
Grossly abnormal serum lipoprotein (Lp) profile which appeared as a broad-midband pattern (BMP) in PAG electrophoresis was detected in 67% of uremic patients maintained by prolonged hemodialysis therapy (hemodialysis patients). It was revealed that BMP was ascribed to the presence of a discrete series of Lps which were intermediate between beta-migrating LDL and pre-beta-migrating VLDL regarding buoyant density, Sf rate, chemical composition, and behavior in electrophoresis. The results in the present study indicate that the accumulation of these Lps, which may include the previously-known Lp species such as the intermediate-density Lp or the remnant particles, is taking place in hemodialysis patients.