Implementation and experience of a web-based allocation system with Pocock and Simon's minimization methods
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Updated: Jun 10, 2026

Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm
Published on: December 9, 2012
Hong Wei Cai1, Jie Lai Xia, Dong Huai Gao
1Information Center, School of Stomatology, The Fourth Military Medical University, 145 Changle West Road, Xi'an, Shaanxi 710032, China. hwcai@fmmu.edu.cn
Abstract:
Minimization is a type of dynamic randomization method that is recommended for use in clinical trials. However, partly due to its organizational complexity in implementation, the utilization of minimization is seldom reported. We developed a centralized random allocation system named "MagMin" using Pocock and Simon's minimization methods, which has been in use since 2006. To date, 5 clinical trials have been randomized using this system, and the other 17 clinical trials are still running on this system. An example is introduced in this paper to describe the implementation of this system. Problems and countermeasures are also discussed.
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