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Updated: Jun 10, 2026

An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
Published on: April 21, 2023
Lineage-specific expansion of DNA-binding transcription factor families
Varodom Charoensawan1, Derek Wilson, Sarah A Teichmann
1MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. varodom@mrc-lmb.cam.ac.uk
Abstract:
DNA-binding domains (DBDs) are essential components of sequence-specific transcription factors (TFs). We have investigated the distribution of all known DBDs in more than 500 completely sequenced genomes from the three major superkingdoms (Bacteria, Archaea and Eukaryota) and documented conserved and specific DBD occurrence in diverse taxonomic lineages. By combining DBD occurrence in different species with taxonomic information, we have developed an automatic method for inferring the origins of DBD families and their specific combinations with other protein families in TFs. We found only three out of 131 (2%) DBD families shared by the three superkingdoms.
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