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Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
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Published on: April 4, 2013

Beam pen lithography.

Fengwei Huo1, Gengfeng Zheng, Xing Liao

  • 1Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, USA.

Nature Nanotechnology
|August 3, 2010
PubMed
Summary
This summary is machine-generated.

Beam pen lithography enables arbitrary nanoscale patterning by passing light through an array of tips. This technique overcomes diffraction limits for applications in electronics and diagnostics.

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Large-area Scanning Probe Nanolithography Facilitated by Automated Alignment and Its Application to Substrate Fabrication for Cell Culture Studies
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Single-Digit Nanometer Electron-Beam Lithography with an Aberration-Corrected Scanning Transmission Electron Microscope
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Last Updated: Jun 10, 2026

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
13:10

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

Large-area Scanning Probe Nanolithography Facilitated by Automated Alignment and Its Application to Substrate Fabrication for Cell Culture Studies
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Single-Digit Nanometer Electron-Beam Lithography with an Aberration-Corrected Scanning Transmission Electron Microscope
10:25

Single-Digit Nanometer Electron-Beam Lithography with an Aberration-Corrected Scanning Transmission Electron Microscope

Published on: September 14, 2018

Area of Science:

  • Nanotechnology
  • Optics
  • Materials Science

Background:

  • Conventional lithography is diffraction-limited, restricting nanoscale feature resolution.
  • Existing methods to overcome diffraction limits are often complex or limit pattern flexibility.
  • Near-field scanning optical microscopy offers sub-diffraction resolution but faces challenges in throughput and scan area.

Purpose of the Study:

  • To develop a massively parallel, high-throughput lithography technique for arbitrary nanoscale pattern generation.
  • To overcome the limitations of conventional and existing near-field lithography methods.
  • To enable the fabrication of nanoscale components for integrated circuits, medical diagnostics, and optoelectronics.

Main Methods:

  • A scanning probe microscopy-based approach utilizing a two-dimensional array of pyramid-shaped elastomeric tips ('pens').
  • Passing 400-nm light through nanoscopic apertures at each tip.
  • The technique, termed beam pen lithography, allows toggling between near- and far-field distances.

Main Results:

  • Achieved arbitrary pattern generation with nanoscale precision.
  • Demonstrated the ability to create features below the diffraction limit (down to 100 nm).
  • Enabled both sub-diffraction limit and larger feature fabrication within a single process.

Conclusions:

  • Beam pen lithography offers a scalable and versatile solution for nanoscale fabrication.
  • The technique overcomes key limitations of existing lithography methods, paving the way for advanced applications.
  • Facilitates the efficient production of complex nanoscale patterns for diverse technological fields.