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Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
Published on: August 16, 2017
Yiyun Zhang1, Runze Li, Chih-Ling Tsai
1Yiyun Zhang is a Senior Statistician, Novartis Pharmaceuticals Corporation ( yiyun.zhang@novartis.com ). Runze Li is the correspondence author and Professor, Department of Statistics and The Methodology Center, The Pennsylvania State University, University Park, PA 16802-2111 ( rli@stat.psu.edu ). Chih-Ling Tsai is Robert W. Glock Chair professor, Graduate School of Management, University of California, Davis, CA, 95616-8609 ( cltsai@ucdavis.edu ).
This study introduces the generalized information criterion (GIC) for selecting regularization parameters in nonconcave penalized likelihood methods. The Bayesian information criterion (BIC)-type selector consistently identifies the true model, unlike the Akaike information criterion (AIC)-type selector which may overfit.
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