Rotating frame spin lattice relaxation in a swine model of chronic, left ventricular myocardial infarction
Walter R T Witschey1, James J Pilla, Giovanni Ferrari
1Department of Radiology, Medical Physics, University Hospital Freiburg, Freiburg im Breisgau, Germany. walter.witschey@uniklinik-freiburg.de
Abstract:
T1ρ relaxation times were quantified in a swine model of chronic, left ventricular myocardial infarction. It was found that there were low frequency relaxation mechanisms that suppress endogenous contrast at low spin-lock amplitudes and in T2-weighted images. A moderate amplitude spin-locking pulse could overcome these relaxation mechanisms. Relaxation dispersion data were measured over a range of RF field amplitudes, and a model was formulated to include dipole-dipole relaxation modulated by molecular rotation and an apparent exchange mechanism. These techniques may find some use in the clinic for the observation of chronic, left ventricular cardiac remodeling.
