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Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

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Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Related Experiment Video

Updated: Jun 10, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Periodontitis and cardiovascular diseases.

Jun-ichi Suzuki1, Norio Aoyama, Masahito Ogawa

  • 1University of Tokyo, Department of Advanced Clinical Science and Therapeutics, Bunkyo, Tokyo 113-8655, Japan. junichisuzuki-circ@umin.ac.jp

Expert Opinion on Therapeutic Targets
|August 4, 2010
PubMed
Summary

Periodontitis, an oral inflammatory condition, is linked to cardiovascular diseases. Periodontal bacteria are frequently found in cardiovascular specimens, suggesting a potential role in disease development.

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Last Updated: Jun 10, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Area of Science:

  • Oral health and its systemic implications.
  • Cardiovascular disease research.
  • Microbiology and immunology.

Background:

  • Periodontitis involves gingival inflammation driven by periodontopathic bacteria.
  • Epidemiological studies indicate periodontitis as a risk factor for cardiovascular diseases (CVDs).
  • Periodontal bacteria have been detected in cardiovascular specimens.

Purpose of the Study:

  • To review the relationship between periodontopathic pathogens and cardiovascular diseases.
  • To highlight the potential role of oral bacteria in CVD development.
  • To encourage further clinical and experimental research.

Main Methods:

  • Review of existing epidemiological reports and scientific studies.
  • Analysis of findings on the presence of periodontal bacteria in cardiovascular samples.
  • Comparison of immune responses (serum IgG titers) in patients with different coronary conditions.

Main Results:

  • Patients with acute coronary syndrome had higher IgG titers to periodontopathic bacteria than those with chronic coronary disease.
  • Periodontal bacteria were found in diseased arteries of patients with Buerger disease and abdominal aortic aneurysm.
  • A potential role for periodontopathic bacteria in CVD development is suggested, though not definitively proven.

Conclusions:

  • Periodontitis and periodontopathic bacteria are associated with cardiovascular diseases.
  • Further clinical and experimental investigations are warranted to establish causality.
  • Understanding this link may lead to new prevention and treatment strategies for CVDs.