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Assessing the palatability of oral rehydration solutions in school-aged children: a randomized crossover trial
Stephen B Freedman1, Dennis Cho, Kathy Boutis
1The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON M5G 1X8, Canada. stephen.freedman@sickkids.ca
Insights
Children found sucralose-sweetened oral rehydration solutions (ORS) more palatable than rice-based ORS. Pedialyte and Pediatric Electrolyte were preferred over Enfalyte, indicating better taste for pediatric hydration.
Area of Science:
- Pediatric Emergency Medicine
- Clinical Nutrition
- Taste Perception
Background:
- Oral rehydration solutions (ORS) are crucial for managing dehydration in children.
- Palatability significantly impacts ORS adherence and effectiveness.
- Limited comparative data exists on the taste profiles of different ORS formulations.
Purpose of the Study:
- To compare the palatability of three distinct oral rehydration solutions in children.
- To evaluate children's preference and willingness to consume different ORS formulations.
Main Methods:
- A prospective, blinded, randomized, 3-period, 3-treatment crossover trial was conducted.
- Sixty-six children (aged 5-10 years) participated in the study.
- Taste was assessed using a visual analog scale, alongside volume consumed and future willingness to drink.
Main Results:
- Sucralose-sweetened ORS (Pedialyte and Pediatric Electrolyte) were significantly more palatable than a rice-based ORS (Enfalyte).
- Pedialyte was the most favored solution (53%), followed by Pediatric Electrolyte (39%), and Enfalyte (8%).
- No significant differences were observed in the volume consumed across the solutions.
Conclusions:
- Sucralose-sweetened ORS demonstrate superior palatability in pediatric populations compared to rice-based alternatives.
- Taste preference is a critical factor influencing ORS consumption in children.
- Findings support the use of more palatable ORS formulations to improve hydration therapy outcomes.
Objective:
To compare the palatability of 3 oral rehydration solutions.
Design:
Prospective, blinded, randomized, 3-period, 3-treatment crossover trial.
Setting:
Emergency department of a tertiary care pediatric hospital.
Participants:
Sixty-six children aged 5 to 10 years with concerns unrelated to the gastrointestinal tract. Intervention Each participant consumed as much of each solution as they desired during a 15-minute period.
Main Outcome Measures:
The primary outcome was each child's rating of taste as measured on a 100-mm visual analog scale (worst taste, 0 mm; best taste, 100 mm). Secondary outcome measures were volume consumed, willingness to consume each liquid again, and the most favored liquid.
Results:
All enrolled patients completed all 3 study periods. A significant carryover effect was detected for taste scores (P=.03), which were significantly different with and without adjustment for the carryover effect (P<.001). Unadjusted values were 65 mm for Pedialyte, 58 mm for Pediatric Electrolyte, and 23 mm for Enfalyte. Differences in mean volume consumed were not significant (Enfalyte, 15 mL; Pediatric Electrolyte, 17 mL; and Pedialyte, 22 mL [P=.44]). The proportion of children who would drink each solution in the future varied significantly between Enfalyte and Pediatric Electrolyte (odds ratio, 0.22; 95% confidence interval, 0.11-0.46) and between Enfalyte and Pedialyte (0.38; 0.25-0.57). There were differences in the identification of the best-tasting solution, with Pedialyte selected by 35 of 66 children (53%), Pediatric Electrolyte by 26 of 66 children (39%), and Enfalyte by 5 of 66 children (8%) (P<.001).
Conclusion:
Sucralose-sweetened oral rehydration solutions (Pedialyte and Pediatric Electrolyte) were significantly more palatable than was a comparable rice-based solution (Enfalyte). Trial Registration clinicaltrials.gov Identifier: NCT00689312.
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Crossover Experiments
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.