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Genetic Screens

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

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Related Experiment Video

Updated: Jun 10, 2026

Large Scale Zebrafish-Based In vivo Small Molecule Screen

Large Scale Zebrafish-Based In vivo Small Molecule Screen

Published on: December 30, 2010

Small molecule screening in zebrafish.

David S Peal¹, Randall T Peterson, David Milan

¹Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

Journal of Cardiovascular Translational Research

|August 4, 2010

Summary

This summary is machine-generated.

Zebrafish screens identify compounds affecting biological pathways and diseases. Advances in chemical screening using zebrafish offer promise for discovering new therapeutic compounds and biological probes.

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Last Updated: Jun 10, 2026

Large Scale Zebrafish-Based In vivo Small Molecule Screen

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Published on: December 30, 2010

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A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

Published on: November 8, 2014

Area of Science:

Chemical Biology
Developmental Biology
Genetics

Background:

Small molecule screens are vital for understanding biological systems and diseases.
Zebrafish (Danio rerio) are increasingly utilized as a whole-organism model for functional screening.

Purpose of the Study:

To review recent advances in small molecule screening approaches in zebrafish.
To discuss methods for identifying small molecule targets and their application in disease models.

Main Methods:

Review of functional small molecule screens in zebrafish.
Focus on modulation of developmental processes and signaling pathways.
Analysis of suppressor screens for disease models.

Main Results:

Zebrafish screens effectively identify compounds impacting signaling pathways and development.
Recent approaches address the challenge of identifying small molecule targets.
Suppressor screens aid in dissecting disease mechanisms.

Conclusions:

Chemical screens in zebrafish are a powerful tool for discovering novel biological probes.
This approach holds significant promise for identifying potential therapeutic compounds.
The field of zebrafish chemical screening is rapidly expanding.