Haloperidol attenuates conditioned place preferences produced by electrical stimulation of the medial prefrontal...

A Conditioned Place Preference test procedure [Ettenberg and Duvauchelle (13)] was used to investigate the effects of dopamine antagonist challenge on the rewarding properties of medial prefrontal cortex (MPFC) electrical stimulation. Rats exhibited strong preferences for the side of a two-compartment test apparatus in which they experienced sessions of experimenter-administered 0.5-s trains of MPFC sine-wave 60-Hz stimulation. Pretreatment with the neuroleptic dopamine antagonist drug, haloperidol (0.0, 0.15, or 0.3 mg/kg IP), resulted in a dose-dependent reduction in the magnitude of observed place preferences. Preference tests were conducted 24 hours after drug-conditioning trials and, hence, were not subject to motoric or other nonspecific actions of the neuroleptic treatments. In a control experiment, haloperidol did not block the place aversions produced by dorsomedial tegmental stimulation. Animals can, therefore, recall place-associations formed in the presence of haloperidol, a result which challenges "state-dependent learning" explanations of the drug's actions. Together, these results are consistent with the view that dopamine neurotransmission is involved in the rewarding consequences of electrical stimulation in the medial prefrontal cortex.