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Updated: Jun 10, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Bone grafting by means of a tunnel dissection: predictable results using stem cells and matrix
Muna Soltan1, Dennis Smiler, Christine Soltan
1soltandds@aol.com
Abstract:
Bone marrow aspirate has been shown to add stem cells, growth factors, and cytokines to bone graft matrices used in bone augmentation sites. The combination of bone marrow aspirate and resorbable scaffold material has a significant osteogenic capability that exceeds that of autogenous bone grafts. This article describes a subperiosteal tunneling technique for applying such grafts to defective sites. Treatment of 2 patients for whom the technique was used to graft 6 deficient sites is described. Histological results and histomorphometric analysis of bone core samples taken from 4 of the 6 grafting sites are also reported. Analysis of the 4 bone cores taken between 4 and 6 months showed a range of 34% to 45% of new bone.

