Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Supervised, Online, Home-Based Eccentric Resistance Exercise Program for Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease.

Gastroenterology research·2026
Same author

Haemochromatosis - a modern clinician's guide.

Internal medicine journal·2026
Same author

Arthritis and High Alcohol Intake at Diagnosis Increase Future Risk of Hepatocellular Carcinoma in <i>HFE</i> Hemochromatosis.

Gastro hep advances·2026
Same author

Reassessing Ferritin Levels in Healthy Older Adults: Updated Reference Ranges and Associated Health Outcomes.

Archives of pathology & laboratory medicine·2026
Same author

National survey of real-world treatment patterns for early- and intermediate-stage hepatocellular carcinoma reveals wide variation across Australian states.

Internal medicine journal·2026
Same author

Protective potential of minimally processed, plant-derived foods against steatotic liver disease in early adulthood.

Clinical nutrition ESPEN·2026

Related Experiment Video

Updated: Jun 10, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Hepatic iron loading in mice increases cholesterol biosynthesis.

Ross M Graham1, Anita C G Chua, Kim W Carter

  • 1School of Medicine and Pharmacology, University of Western Australia, Perth, WA, Australia. rmgraham@meddent.uwa.edu.au

Hepatology (Baltimore, Md.)
|August 5, 2010
PubMed
Summary

High iron levels in the liver boost cholesterol synthesis, potentially worsening fatty liver disease. This study clarifies iron

More Related Videos

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
08:58

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Published on: March 11, 2017

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

Related Experiment Videos

Last Updated: Jun 10, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
08:58

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Published on: March 11, 2017

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
05:08

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

Area of Science:

  • Biochemistry
  • Metabolic Regulation
  • Hepatology

Background:

  • Iron and cholesterol are vital metabolites with clinical implications.
  • Both iron and cholesterol are linked to hepatic steatosis and oxidative stress.
  • The precise interaction between iron status and cholesterol metabolism remains unclear.

Purpose of the Study:

  • To investigate the impact of iron status on hepatic cholesterol synthesis.
  • To elucidate the role of iron in lipid metabolism within the liver.

Main Methods:

  • Studied mice with varying iron levels to assess hepatic cholesterol synthesis.
  • Analyzed gene expression of cholesterol biosynthesis enzymes.
  • Correlated hepatic iron concentration with cholesterol content and regulatory factors.

Main Results:

  • Up-regulation of seven cholesterol biosynthesis enzyme transcripts with increased hepatic iron.
  • Positive correlation between hepatic iron and hepatic cholesterol content.
  • No significant relationship found between plasma cholesterol and hepatic iron or cholesterol.

Conclusions:

  • Hepatic iron loading enhances liver cholesterol synthesis.
  • This provides a novel mechanism linking iron to fatty liver disease and lipotoxicity.