Related Experiment Video
Updated: Jun 10, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
[The relationship between the duration and severity of asthma]
Kazuharu Tsukioka1, Shin-ichi Toyabe, Kouhei Akazawa
1Niigata Allergic Disease Research Institute/Tsukioka Clinic for Internal Medicine.
Background:
The relationship between the duration and severity of asthma has not been comprehensively investigated.
Methods:
We examined the relationship between duration of asthma and asthma severity among 4776 patients with asthma: 608 with childhood-onset persistent asthma (12.7%), 187 with adolescent-onset asthma (3.9%), and 3981 with adult-onset asthma (83.4%). The assessment of asthma severity was based on the Japanese Guidelines for The Diagnosis and Treatment of Allergic Diseases, 2007 (JGL 2007).
Results:
Asthma severity was assessed at 2 years, 3 to 10 years. 11 to 20 years, and 21 years or longer after disease onset. Disease severity significantly increased with greater asthma duration (p<0.001). This relationship was not affected by serum total IgE concentration (<300 IU/ml vs > or = 300 IU/ml), smoking status, house dust mite-specific serum IgE antibody level, or gender.
Conclusion:
Our findings suggest that bronchial asthma is a disease that worsens over time.
Related Concept Videos
Asthma-III: Symptoms and Complications
Classification of Asthma
Asthma I: Introduction
Asthma-I: Introduction
Asthma III: Clinical Manifestations
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
