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Published on: May 8, 2020
[Lymphocyte GRK2 expression of the very elderly with chronic heart failure]
Wen-qian Gao1, Jin-ling Ma, Chun-guang Han
1Department 1 of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing 100853, China. gwqbj08@sina.com
Objective:
To explore the correlation of lymphocyte G protein-coupled receptor kinases 2 (GRK2) expression of the very elderly with chronic heart failure (HF) and heart ejection fraction (EF).
Methods:
16 elderly patients with chronic heart failure were divided into 2 groups as following: EF < 45% (n=7), EF > or = 45% (n=9); and health elderly as control (n=8). Lymphocytes were obtained from blood, reverse transcription polymerase chain reaction were used to measure GRK2 mRNA levels.
Results:
Lymphocyte GRK2 mRNA levels of EF < 45% group were higher than that of EF > 45% group, which were greater than that of control.
Conclusion:
Elevation of lymphocyte GRK2 levels in HF is associated with heart EF, lymphocytes may provide a surrogate for monitoring cardiac GRK2 in human HF.
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