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DNA Microarrays

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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Molecularly imprinted polymer sensor arrays.

Ken D Shimizu¹, Clifton J Stephenson

¹Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, USA. shimizu@mail.chem.sc.edu

Current Opinion in Chemical Biology

|August 6, 2010

Summary

This summary is machine-generated.

Molecularly imprinted polymer (MIP) sensor arrays enhance selectivity by combining multiple polymers with varied binding affinities. This approach effectively discriminates analytes, even those not used during MIP imprinting.

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Polymer Microarrays for High Throughput Discovery of Biomaterials

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Published on: January 25, 2012

Area of Science:

Polymer Science
Analytical Chemistry
Sensor Technology

Background:

Sensor arrays transform modest selectivity sensors into highly selective devices.
Developing new sensor arrays requires diverse recognition elements with varied binding affinities.
Molecularly imprinted polymers (MIPs) offer unique advantages as recognition elements.

Purpose of the Study:

To highlight the advantages of using MIPs in sensor arrays.
To demonstrate the effectiveness of MIP sensor arrays in analyte discrimination.
To showcase the tailorability and broad utility of MIP sensor arrays.

Main Methods:

Utilizing MIPs as recognition elements in sensor arrays.
Leveraging the imprinting process to tune MIP selectivity.
Employing the array format to enhance overall sensor performance.

Main Results:

MIP sensor arrays can be rapidly and inexpensively prepared with tunable selectivities.
The array format compensates for the inherent low selectivities and high cross-reactivities of individual MIP sensors.
MIP sensor arrays demonstrate effective discrimination of analytes, including those not used as imprinting templates.

Conclusions:

MIP sensor arrays are a viable and versatile approach for creating highly selective sensors.
The imprinting process allows for tailoring MIP sensor arrays to specific analytes.
MIP sensor arrays exhibit broad utility and effective analyte discrimination capabilities.