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Development and in vitro evaluation of ibuprofen mouth dissolving tablets using solid dispersion technique
Sunil Kumar Jain1, Meenakshi Shukla, Vivek Shrivastava
1SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, India. suniljain25in@yahoo.com
Chemical & Pharmaceutical Bulletin
|August 6, 2010
Summary
This study developed improved mouth dissolving tablets for ibuprofen using solid dispersion technology. The optimized formulation demonstrated enhanced drug release and faster disintegration compared to commercial ibuprofen tablets.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Solid State Chemistry
Background:
- Ibuprofen (IBU) is a widely used non-steroidal anti-inflammatory drug.
- Improving the dissolution rate and bioavailability of poorly soluble drugs like ibuprofen is a significant challenge in pharmaceutical formulation.
- Mouth dissolving tablets offer an alternative dosage form for improved patient compliance and rapid drug absorption.
Purpose of the Study:
- To prepare and evaluate ternary solid dispersions (SD) of ibuprofen (IBU) to enhance its dissolution profile.
- To formulate and characterize ibuprofen mouth dissolving tablets using optimized SD.
- To compare the performance of the developed ibuprofen mouth dissolving tablets with a marketed product.
Main Methods:
- Ternary solid dispersions of IBU were prepared using Polyethylene Glycol 4000 (PEG 4000) as a carrier and Tween 80 as a surfactant via solvent evaporation and melt solvent methods.
- Solid dispersions were characterized using Fourier Transform Infra-Red (FT-IR) spectroscopy, Differential Scanning Calorimetry (DSC), and X-ray Diffraction (XRD).
- Mouth dissolving tablets were formulated using the optimized SD (carrier:drug:surfactant ratio 10:5:1) with super-disintegrants and evaluated for disintegration time and in vitro drug release.
Main Results:
- Solid dispersion formation resulted in the conversion of crystalline ibuprofen to an amorphous form, as confirmed by FT-IR and XRD.
- DSC studies indicated complete dissolution of ibuprofen within the PEG 4000 carrier.
- Mouth dissolving tablets containing 12% Ac-Di-Sol exhibited rapid disintegration (202s) and high in vitro drug release (84.57%).
- Drug release kinetics followed the Peppas-Korsmeyer model (r>0.99, n=0.44-0.67).
- Tablets containing solid dispersion showed a superior dissolution profile compared to commercial ibuprofen tablets.
Conclusions:
- Ternary solid dispersion is an effective technique for enhancing the dissolution of ibuprofen.
- The developed ibuprofen mouth dissolving tablets offer improved therapeutic efficacy due to faster disintegration and enhanced drug release.
- The optimized formulation holds potential as a superior alternative to conventional ibuprofen tablets.
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