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Updated: Jun 10, 2026
Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
Synthesis, crystal structure, antioxidant activity, and DNA-binding studies of a novel Ni(II) [2x2] grid complex with
1Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P.R. China.
Abstract:
With a bistridentate Schiff-base ligand, N',N'(3)-bis[(1E)-1-(2-pyridinyl)ethylidene)] isophthalohydrazide (H(2)L), a [2x2]G grid complex, [Ni(4)(HL)(4)](ClO(4))(4).4H(2)O.0.5 CH(3)OH (1) has been synthesized and characterized spectroscopically and crystallographically. Spectrometric titrations, ethidium bromide displacement experiments, circular dichroism spectral analysis and viscosity measurements indicate that the compound 1 strongly binds with calf-thymus DNA, presumably via intercalation mechanism. Furthermore, the antioxidant activity (superoxide and hydroxyl radical) of the ligand and its nickel(II) complex is determined by using spectrophotometer methods in vitro. Complex 1 is found to possess potent antioxidant activity and be better than standard antioxidants like mannitol.
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