Enantioselective formal total synthesis of dihydrospirotryprostatin B
Tian-Feng Peng1, Peng Liu1, Yu-Xin Guo1
1College of Chemistry and Environmental Science, Qujing Normal University, Qujing 655011, China.
Abstract:
Spirotryprostatins are representative members of medicinally interesting bioactive molecules of the spirooxindole natural products. In this communication, we present a novel enantioselective total synthesis of the spirooxindole alkaloid dihydrospirotryprostatin B. The synthesis takes advantage of copper-catalyzed tandem reaction of o-iodoanilide chiral sulfinamide derivatives with alkynone to rapidly construct the key quaternary carbon stereocenter of the natural product dihydrospirotryprostatin B.
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