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Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
Late pregnancy screening for human immunodeficiency virus
1Division of Infectious Diseases, Department of Pediatrics, Ochsner Children's Health Center, New Orleans, LA 70121, USA. RWSteele@aol.com
The Pediatric Infectious Disease Journal
|August 6, 2010
Summary
Late pregnancy screening for human immunodeficiency virus (HIV) is recommended. Three infants born to mothers who initially tested negative for HIV during early pregnancy were infected, highlighting the need for universal screening.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Pediatrics
Background:
- Routine human immunodeficiency virus (HIV) screening is standard during early pregnancy.
- The study focuses on cases where mothers initially tested negative for HIV in the first trimester.
Observation:
- Three infants were born to mothers with initially negative HIV screening results.
- These mothers were not retested later in pregnancy due to perceived low risk.
- Maternal HIV infection was detected shortly after childbirth in all three cases.
Findings:
- Two out of the three infants born to these mothers acquired HIV infection.
- This suggests potential for late-term transmission or acquisition during pregnancy.
Implications:
- The findings support universal HIV screening for all pregnant women, including late pregnancy screening.
- Implementing late pregnancy HIV testing can help prevent mother-to-child transmission of HIV.

