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Related Experiment Video

Updated: Jun 10, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Physical methods for preventing deep vein thrombosis in stroke.

Marcello Naccarato¹, Fabio Chiodo Grandi, Martin Dennis

¹U.C.O. Clinica Neurologica, University of Trieste, Ospedale di Cattinara, Trieste, Italy, 34100.

The Cochrane Database of Systematic Reviews

|August 6, 2010

Summary

Physical methods like graduated compression stockings (GCS) do not reduce deep vein thrombosis (DVT) risk in stroke patients. More research is needed for intermittent pneumatic compression (IPC) to determine its effectiveness and safety for DVT prevention post-stroke.

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Area of Science:

Medical research
Clinical trials
Vascular medicine

Background:

Deep vein thrombosis (DVT) and pulmonary embolism (PE) are significant complications following stroke.
Physical prophylaxis methods, including graduated compression stockings (GCS) and intermittent pneumatic compression (IPC), are used to prevent DVT in surgical patients.
The efficacy and safety of these physical methods in stroke patients require specific investigation.

Purpose of the Study:

To evaluate the effectiveness and safety of physical methods in preventing DVT, fatal or non-fatal PE, and death in individuals who have recently experienced a stroke.
To determine if GCS or IPC offer a significant benefit in reducing thrombotic events and mortality after stroke.

Main Methods:

A systematic search of multiple electronic databases (Cochrane Stroke Group, CENTRAL, MEDLINE, EMBASE, CINAHL, British Nursing Index) was conducted up to November 2009.
Included were unconfounded randomized controlled trials comparing physical DVT prophylaxis with control, initiated within seven days of stroke onset.
Data extraction was performed by two independent reviewers.

Main Results:

Two trials (2615 patients) assessed GCS, and two small studies (177 patients) assessed IPC.
Overall, physical methods did not significantly reduce DVT during treatment (OR 0.85) or deaths (OR 1.12).
GCS showed no significant reduction in DVT or death; IPC demonstrated a non-significant trend towards lower DVT risk (OR 0.45) without affecting mortality.

Conclusions:

Current evidence from randomized trials does not support the routine use of GCS for DVT prevention in acute stroke patients.
Insufficient evidence exists to recommend routine IPC use in acute stroke; larger randomized studies are necessary to clarify its risk-benefit profile.