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Updated: Jun 10, 2026
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
Published on: January 23, 2018
Interventions for treating osteochondral defects of the talus in adults
David Loveday1, Rupert Clifton, Andrew Robinson
1Department of Orthopaedics, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge, Cambridgeshire, UK, CB2 0QQ.
Background:
Osteochondral defects of the talus are usually a consequence of trauma. They can cause chronic pain and serious disability. Various interventions, non-surgical and surgical, have been used for treating these defects.
Objectives:
The objective of this review is to determine the benefits and harms of the interventions used for treating osteochondral defects of the talus in adults.
Search Strategy:
We searched the Cochrane Bone, Joint and Muscle Trauma Group Specialised Register, the Cochrane Central Register of Controlled Trials, MEDLINE, MEDLINE In-Process, EMBASE, Current Controlled Trials, the WHO International Clinical Trials Registry Platform and reference lists of articles. Date of last search: December 2009.
Selection Criteria:
Eligible for inclusion were any randomised or quasi-randomised controlled clinical trials evaluating interventions for treating osteochondral defects of the talus in adults. Our primary outcomes included pain, ankle function, treatment failure (unresolved symptoms or reoperation) and health-related quality of life. Preference was given to validated, patient-reported outcome measures.
Data Collection And Analysis:
Two review authors independently evaluated trials for inclusion and, for the included trial, independently assessed the risk of bias and extracted data.
Main Results:
One small trial with 15 participants and six months follow-up was included. This trial was published only as a conference abstract, which provided inadequate information to judge the trial's methods and no numerical results. The trial reported that a series of three intra-articular hyaluronan injections started three weeks after arthroscopic microfracture did not to improve pain but may have improved one aspect of mobility. There were no available data to check this claim.
Authors' Conclusions:
There is insufficient evidence from randomised trials to determine which interventions are best for osteochondral defects of the talus in adults. High quality randomised trials are required to guide non-surgical and surgical treatment decisions for these injuries.
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