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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
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Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

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Related Experiment Video

Updated: Jun 10, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

Wilms' tumor.

Carlos H Martínez1, Sumit Dave, Jonathan Izawa

  • 1Department of Surgery, Schulich School of Medicine & Dentistry, the University of Western Ontario, London Health Sciences Centre-Victoria Hospital, London, Ontario, Canada.

Advances in Experimental Medicine and Biology
|August 7, 2010
PubMed
Summary

Wilms

Area of Science:

  • Pediatric Oncology
  • Genetics
  • Molecular Biology

Background:

  • Wilms' tumor (nephroblastoma) is the most common pediatric kidney cancer.
  • It is linked to congenital anomalies and syndromes.
  • Genetic and molecular studies have advanced understanding of its development.

Purpose of the Study:

  • To provide a balanced overview of current knowledge on Wilms' tumor.
  • To highlight advancements in translational and clinical research.
  • To discuss the role of genetics in organogenesis and prognosis.

Main Methods:

  • Review of genetic and molecular biology studies.
  • Analysis of translational medicine findings.
  • Examination of clinical prognosis factors.

Related Experiment Videos

Last Updated: Jun 10, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

  • Overview of multi-institutional therapeutic trial outcomes.

    • Main Results:

    • Genetics research has identified critical genes in Wilms' tumor development.
    • Emerging markers show potential for improving clinical prognosis.
    • Multidisciplinary efforts have significantly improved therapeutic outcomes over 40 years.

    Conclusions:

    • Wilms' tumor research has progressed significantly through genetic and molecular studies.
    • Translational medicine offers new avenues for prognosis.
    • Collaborative clinical trials have established a model for pediatric cancer treatment.