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Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease

Published on: August 26, 2017

Microscopic polyangiitis.

Sharon A Chung¹, Philip Seo

¹Division of Rheumatology, Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, CA, USA.

Rheumatic Diseases Clinics of North America

|August 7, 2010

Summary

This summary is machine-generated.

Microscopic polyangiitis (MPA) is a small-vessel vasculitis often treated with cytotoxic agents and glucocorticoids. Current research seeks alternative therapies to reduce reliance on these potent drugs.

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Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes

Published on: October 7, 2018

Area of Science:

Rheumatology
Immunology
Pathology

Background:

Microscopic polyangiitis (MPA) is a systemic vasculitis distinct from classical periarteritis nodosa.
It involves small-caliber blood vessels and is associated with antineutrophil cytoplasmic antibodies.
MPA commonly affects the kidneys (glomerulonephritis) and lungs (pulmonary capillaritis).

Purpose of the Study:

To review the history, pathogenesis, clinical manifestations, and treatment of microscopic polyangiitis.
To highlight current research into alternative treatment strategies for MPA.

Main Methods:

Literature review of historical descriptions and recent research.
Analysis of pathogenesis, clinical presentation, and treatment modalities.

Main Results:

MPA is characterized by small-vessel inflammation and specific autoantibodies.
Standard treatment involves cytotoxic agents and high-dose glucocorticoids.
Emerging research focuses on minimizing cytotoxic agent exposure.

Conclusions:

Understanding MPA's history and pathogenesis is crucial for effective management.
Current treatment paradigms are being re-evaluated to improve patient outcomes.
Future research aims to develop safer and equally effective MPA therapies.