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Urinary retention--an unusual dystonic reaction to continuous metoclopramide infusion
M Kohli-Kumar1, A D Pearson, I Sharkey
1Children's Hospital Medical Center, Cincinnati, OH.
DICP : the Annals of Pharmacotherapy
|May 1, 1991
Abstract:
Vomiting is one of the most distressing adverse effects of cancer chemotherapy. Metoclopramide by continuous infusion (400 micrograms/kg/h after a loading dose of 2.5 mg/kg) is a novel administration method for optimizing efficacy. A two-year-old boy developed urinary retention on three occasions, once accompanied by priapism and slurred speech, while receiving a continuous infusion. This was reversed by procyclidine, suggesting that it may have been a dystonic reaction.