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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Recombinant DNA01:09

Recombinant DNA

Overview
Recombinant DNA01:09

Recombinant DNA

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GeneCards Version 3: the human gene integrator.

Marilyn Safran1, Irina Dalah, Justin Alexander

  • 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. marilyn.safran@weizmann.ac.il

Database : the Journal of Biological Databases and Curation
|August 7, 2010
PubMed
Summary
This summary is machine-generated.

GeneCards Version 3 offers enhanced human gene information with advanced search and gene-set analysis tools. This update improves data integration and visualization for biomedical researchers, aiding in gene discovery and drug targeting.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Human Genetics

Background:

  • GeneCards is a widely used, comprehensive resource for human gene information.
  • It integrates data from over 80 sources for >73,000 gene entries.
  • Previous versions have served the biomedical research community for nearly 15 years.

Purpose of the Study:

  • To introduce GeneCards Version 3, highlighting its new features and infrastructure.
  • To emphasize the enhanced capabilities for gene-set analyses and their applications.
  • To detail data and functional enhancements for improved gene research.

Main Methods:

  • Development of a new, sophisticated search engine and infrastructure.
  • Implementation of gene-set analysis tools: GeneALaCart and GeneDecks.
  • Augmentation of data visualization, including gene expression, splicing, SNPs, and pathways.

Main Results:

  • GeneCards Version 3 provides a faster, more powerful platform for accessing gene information.
  • New features facilitate gene-set analyses, aiding in microarray analysis and drug target identification.
  • Expanded data sections include enhanced visualization, alternative splicing, SNPs, pathways, and research reagents.

Conclusions:

  • GeneCards Version 3 represents a significant upgrade, offering advanced tools for biomedical research.
  • The enhanced features support a wider range of applications, from gene discovery to drug development.
  • The platform continues to be a vital resource for comprehensive human gene annotation.