Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Timing matters: sex differences in treatment limitation decisions in intensive care.

Critical care (London, England)·2026
Same author

Ratio of Left Atrial and Ventricular Volume as New Marker of Atrial Cardiopathy and Stroke Risk.

Stroke·2026
Same author

Neural resilience improves survival in cardiovascular patients.

Cardiovascular research·2026
Same author

Bidirectional brain-heart interactions in health and disease.

Nature reviews. Neurology·2026
Same author

Decoding sex and gender effects on health: evidence from a nationwide cohort.

Biology of sex differences·2026
Same author

The junctional protein associated with coronary artery disease predicts adverse cardiovascular events in patients with acute coronary syndromes at high residual risk.

European heart journal·2025
Same journal

Exploring the Role of Hypusine Signaling in Vascular Smooth Muscle Cells for Mitigating Restenosis in Coronary Artery Disease.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same journal

Circulating Extracellular Mitochondria Perpetuate Endothelial Damage via Cardiolipin-Mediated Mitophagic Overload.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same journal

Myeloid Cell-Specific Deletion of LGR4 Suppresses Atherosclerotic Lesion Formation.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same journal

Building Resilience in Academic Science and Medicine.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same journal

Endothelial Continuum and Capillary Specialization in Pulmonary Vascular Development.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same journal

Systematic Review and Meta-Analysis Examining the Effect of Upregulation and Inhibition of Proprotein Convertase Subtilisin/Kexin Type 9 in Mouse Models of Abdominal Aortic Aneurysm.

Arteriosclerosis, thrombosis, and vascular biology·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Aging induces endothelial dysfunction while sparing arterial thrombosis.

Simon F Stämpfli1, Alexander Akhmedov, Cathérine Gebhard

  • 1Cardiovascular Research, Institute of Physiology, University of Zurich, Zurich, Switzerland.

Arteriosclerosis, Thrombosis, and Vascular Biology
|August 7, 2010
PubMed
Summary
This summary is machine-generated.

Aging does not directly increase arterial thrombus formation in mice. This study found no significant difference in thrombosis between aged and young mice, highlighting the importance of managing other cardiovascular risk factors.

More Related Videos

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
06:14

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

Published on: June 11, 2017

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium
11:00

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

Published on: June 22, 2010

Related Experiment Videos

Last Updated: Jun 10, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
06:14

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

Published on: June 11, 2017

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium
11:00

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

Published on: June 22, 2010

Area of Science:

  • Cardiovascular Science
  • Aging Research
  • Hemostasis and Thrombosis

Background:

  • Aging is a significant risk factor for cardiovascular diseases, particularly arterial thrombosis.
  • Directly assessing aging's impact on vascular homeostasis is challenging in humans due to confounding risk factors.
  • Murine models offer a unique system to study aging's effects independently of other risk factors.

Purpose of the Study:

  • To investigate the direct influence of aging on arterial thrombus formation.
  • To compare thrombosis potential in aged (2-year-old) versus young (11-week-old) C57Bl6 mice.

Main Methods:

  • Utilized organ chamber experiments to confirm aging status.
  • Induced arterial thrombosis via photochemical injury in aged and young mice.
  • Assessed key hemostatic markers including tissue factor expression, coagulation times, and platelet activation.

Main Results:

  • Confirmed advanced aging in older mice via organ chamber experiments.
  • Photochemical injury-induced arterial thrombosis was comparable between aged and young mice.
  • Key hemostatic parameters (tissue factor, inhibitors, coagulation times, platelet activation) showed no significant age-related differences.

Conclusions:

  • Aging per se does not appear to promote arterial thrombosis in this mouse model.
  • Findings suggest that other modifiable risk factors play a crucial role in age-related cardiovascular events.
  • While not directly extrapolatable to humans, the study provides valuable insights into aging's isolated effect on thrombosis.