Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 10, 2026

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Applications of tissue microarray technology.

Ronald Simon1

  • 1Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany. r.simon@uke.de

Methods in Molecular Biology (Clifton, N.J.)
|August 7, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond EML4: efficacy of targeted therapy in lung cancer patients with rare ALK fusions - a real-world retrospective analysis.

NPJ precision oncology·2026
Same author

Prevalence of heterozygous and homozygous 9p21 deletions in human cancer: a tissue microarray study on 4,999 tumors from 125 different tumor types.

Molecular medicine (Cambridge, Mass.)·2026
Same author

Glutathione peroxidase 2 expression in human tumors: a tissue microarray study on 18,555 tumors.

Frontiers in oncology·2026
Same author

Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany.

International journal of cancer·2026
Same author

Time dependent outcomes modeling in a real-world analysis of the molecular tumor board at University Cancer Center Hamburg (2016-2022).

The oncologist·2026
Same author

Low E-cadherin expression is associated with poor prognosis in pulmonal adenocarcinoma.

Scientific reports·2026
Same journal

Mapping the 3D Chromosome Organization of a Biosynthetic Gene Cluster by Capture Hi-C (CHi-C).

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Mapping the 3D Chromosome Organization of Streptomyces by Hi-C.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

CUT&Tag Epigenomic Profiling of Biosynthetic Gene Clusters in Arabidopsis thaliana.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Rhizobium rhizogenes-Mediated Hairy Root Transformation Protocol for Lotus japonicus and Other Legumes.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Characterization of Bioactive Saponins from Sea Cucumbers.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Methods for Functional Validation of Terpenoid Metabolic Clusters in Nicotiana benthamiana and Aspergillus oryzae.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Tissue microarrays (TMAs) are versatile tools for biological research. Different TMA types, including prevalence, progression, and prognosis arrays, enable comprehensive analysis of molecular markers in cancer and other diseases.

Area of Science:

  • Biomedical research
  • Oncology
  • Pathology

Background:

  • Tissue microarrays (TMAs) are widely adopted for tissue-based investigations.
  • TMAs facilitate high-throughput analysis of molecular markers in various diseases.

Purpose of the Study:

  • To outline the common types and applications of TMAs in research.
  • To highlight the utility of TMAs in cancer research and other fields.

Main Methods:

  • Categorization of TMAs based on data availability: prevalence, progression, and prognosis arrays.
  • Integration of normal tissue arrays for comparative analysis.

Main Results:

  • Prevalence TMAs: Estimate alteration frequency.
  • Progression TMAs: Study marker roles in tumor development and metastasis.

More Related Videos

Manual Construction of a Tissue Microarray using the Tape Method and a Handheld Microarrayer
12:03

Manual Construction of a Tissue Microarray using the Tape Method and a Handheld Microarrayer

Published on: June 10, 2022

Related Experiment Videos

Last Updated: Jun 10, 2026

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
09:32

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies

Published on: September 23, 2014

Manual Construction of a Tissue Microarray using the Tape Method and a Handheld Microarrayer
12:03

Manual Construction of a Tissue Microarray using the Tape Method and a Handheld Microarrayer

Published on: June 10, 2022

  • Prognosis TMAs: Uncover clinical impact of markers using patient follow-up data.

    • Conclusions:

    • TMAs, including prevalence, progression, and prognosis types, offer a rapid and thorough method for analyzing molecular markers in human cancers.
    • TMAs are also valuable tools for non-cancerous research, such as in Alzheimer's and inflammatory diseases.