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Published on: August 28, 2018

Clinical utility of serum cystatin C in predicting coronary artery disease

Mevlut Koc1, Mustafa Kemal Batur, Osman Karaarslan

  • 1Adana Numune Education and Research Hospital, Department of Cardiology, Adana, Turkey. mevlutkoc78@yahoo.com

Cardiology Journal
|August 7, 2010
PubMed

Insights

Cystatin C effectively predicts coronary artery disease (CAD) presence and severity. This biomarker correlates with key atherosclerotic risk factors, offering clinical utility in patient management.

Area of Science:

  • Cardiology
  • Biochemistry
  • Clinical Diagnostics

Background:

  • Limited data exists on cystatin C's utility in stable coronary artery disease (CAD).
  • Current understanding of cystatin C's role in atherosclerosis risk is incomplete.

Purpose of the Study:

  • To evaluate cystatin C's predictive value for CAD presence and severity.
  • To assess cystatin C's association with biochemical risk factors for atherosclerosis.

Main Methods:

  • Included 94 CAD patients and 92 controls with cardiovascular risk factors.
  • Performed echocardiography and laboratory tests, stratifying subjects by cystatin C quartiles.
  • Analyzed associations between cystatin C levels and CAD characteristics.

Main Results:

  • Increased CAD prevalence observed with higher cystatin C quartiles (p < 0.001).
  • Cystatin C independently predicted incident CAD alongside hs-CRP, eGFR, HDL, and SBP.
  • Cystatin C correlated with CAD severity (b = 0.258, p < 0.01) and atherosclerotic risk factors (homocysteine, creatinine, hs-CRP).

Conclusions:

  • Cystatin C shows potential as a valuable laboratory tool for predicting CAD presence and severity.
  • Cystatin C significantly correlates with key biochemical risk factors for CAD, including homocysteine, low HDL, and CRP.
Abstract

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