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Updated: Jun 10, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
A questionnaire assessment of physical function in hyperlipidemic patients
Regina M Taylor-Gjevre1, Anthony Wassef, Bindu Nair
1Department of Medicine, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. r.gjevre@usask.ca
Summary
Lipid-lowering drug therapy (LLT) does not adversely affect physical functioning or quality of life. Men on LLT showed improved physical function scores compared to those on non-pharmacological therapy.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Quality of Life Research
Background:
- Lipid-lowering drug therapy (LLT) is associated with potential myopathic effects.
- The impact of LLT on patient quality of life and physical functioning remains unclear.
Purpose of the Study:
- To prospectively evaluate the effect of LLT on physical functioning.
- To compare physical functioning and quality of life in patients receiving LLT versus non-pharmacological therapy (NPT).
Main Methods:
- Prospective cohort study involving 112 patients from a risk reduction clinic.
- Data collected via questionnaires including SF-36 Physical Function Score (PF) and modified Health Assessment Questionnaire (mHAQ).
- Patients were categorized into LLT (statins/fibrates) or NPT (diet/exercise) groups.
Main Results:
- No significant differences in baseline characteristics or outcomes were observed between LLT and NPT groups for females.
- Men receiving LLT demonstrated significantly better SF-36 PF scores compared to men in the NPT group (p=0.037).
- No adverse effects on physical functioning or quality of life were detected in the LLT group.
Conclusions:
- LLT does not appear to negatively impact physical functioning or quality of life.
- Men treated with LLT may experience enhanced physical functioning compared to non-pharmacological approaches.
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