Drug-induced liver disease
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Updated: Jun 10, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Jiwon W Kim1, Akiko Hattori, Paula V Phongsamran
1Department of Clinical Pharmacy and Pharmaceutical Economics and Policy, University of Southern California School of Pharmacy, USC University Hospital, 1500 San Pablo Street, Los Angeles, CA 90033, USA. jiwonkim@usc.edu
Abstract:
More than 1000 drugs have been associated with hepatic injury, which can present in all forms of acute and chronic liver disease. The identification and prevention of drug-induced liver disease remain challenging tasks for health care professionals as reliable and practical assessment tools are not currently available to diagnose drug-induced liver disease. The management of drug-induced liver injury is generally supportive, and the recognition and avoidance of causative agents remain the most effective strategy for positive clinical outcomes.
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