Related Experiment Video
Updated: Jun 10, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
Published on: January 12, 2022
Identification of new pathogens in the intraocular fluid of patients with uveitis
Jolanda D F de Groot-Mijnes1, Lenneke de Visser, Stephanie Zuurveen
1Department of Virology, University Medical Center Utrecht, The Netherlands. J.D.FdeGroot@umcutrecht.nl
Purpose:
To determine infectious causes in patients with uveitis of unknown origin by intraocular fluids analysis.
Design:
Case-control study.
Methods:
Ocular fluids from 139 patients suspected of infectious uveitis, but negative for herpes simplex virus, varicella-zoster virus, cytomegalovirus, and Toxoplasma gondii by polymerase chain reaction and/or antibody analysis in intraocular fluids, were assessed for the presence of 18 viruses and 3 bacteria by real-time polymerase chain reaction (PCR). The ocular fluids from 48 patients with uveitis of known etiology or with cataract were included as controls.
Results:
Positive PCR results were found for Epstein-Barr virus, for rubella virus, and for human herpesvirus 6 each in 1 patient and for human parechovirus in 4 patients. Of the human parechovirus-positive patients, 1 was immunocompromised and had panuveitis. The other 3 patients were immunocompetent and had anterior uveitis, all with corneal involvement.
Conclusions:
Human parechovirus might be associated with infectious (kerato)uveitis.
Related Concept Videos
Microbiome of the Eye
Rapid Identification of Pathogens
Glaucoma: Overview

