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Prognostic value of osteoprotegerin in chronic heart failure: The GISSI-HF trial

Ragnhild Røysland1, Serge Masson, Torbjørn Omland

  • 1Division of Medicine, Akershus University Hospital, Lørenskog, Norway.

American Heart Journal
|August 10, 2010
PubMed

Insights

Osteoprotegerin (OPG) predicts death in chronic heart failure (CHF) patients, independent of traditional risk factors. Higher OPG levels are linked to increased mortality and cardiovascular events in this population.

Area of Science:

  • Cardiology
  • Biomarkers
  • Heart Failure Research

Background:

  • Osteoprotegerin (OPG) is a tumor necrosis factor receptor superfamily member.
  • Elevated OPG levels predict mortality and hospitalization in acute coronary syndrome patients.
  • The prognostic value of OPG in chronic heart failure (CHF) remains unestablished.

Purpose of the Study:

  • To investigate the association between plasma osteoprotegerin (OPG) levels and clinical outcomes in patients with chronic heart failure (CHF).

Main Methods:

  • 1,229 CHF patients from the GISSI-HF trial had baseline plasma OPG measured via ELISA.
  • Patients were randomized to n-3 polyunsaturated fatty acids, rosuvastatin, or placebo.
  • Cox proportional hazards regression models assessed the relationship between OPG and outcomes.

Main Results:

  • During a median 3.9-year follow-up, 332 deaths and 791 cardiovascular deaths/hospitalizations occurred.
  • Baseline OPG strongly predicted death (HR 1.53 per SD increase, univariate).
  • OPG remained a significant predictor of death (HR 1.20) and composite endpoint (HR 1.34) after risk factor adjustment.

Conclusions:

  • Osteoprotegerin (OPG) is an independent predictor of mortality in patients with chronic heart failure (CHF).
  • OPG provides prognostic information beyond conventional cardiovascular risk factors in CHF.
Abstract

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