Related Experiment Video
Updated: Jun 10, 2026
08:24
Experimental Assessment of Mouse Sociability Using an Automated Image Processing Approach
Published on: May 15, 2016
A survey of internet resources for mouse development
1Transgenic Animal Model Core, Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Methods in Enzymology
|August 10, 2010
Summary
Online resources significantly enhance mouse developmental biology research by providing comprehensive anatomical and gene expression atlases. These digital tools facilitate the study of genetic perturbations and regulatory gene networks in mouse models.
Area of Science:
- Developmental Biology
- Genomics
- Bioinformatics
Background:
- The internet offers vast resources for mouse developmental biology research, including anatomical and gene expression atlases.
- Online atlases surpass print versions in image quantity and specialized terminology, enhancing data accessibility and depth.
- Gene expression data and microarray analyses are available in online repositories, aiding in the study of developmental processes.
Purpose of the Study:
- To discuss the utility of online resources for mouse developmental biology research.
- To highlight the advantages of digital atlases and repositories over traditional methods.
- To explore how these resources aid in identifying regulatory gene networks and testing hypotheses.
Main Methods:
- Utilizing online anatomical and gene expression atlases for comparative analysis.
- Employing bioinformatic tools to interrogate gene expression data and identify regulatory networks.
- Leveraging genetically engineered mouse models, such as those from the Knockout Mouse Project (KOMP), for in vivo validation.
Main Results:
- Online atlases provide extensive image data and detailed ontologies, improving research capabilities.
- Gene expression data facilitates comparisons with mouse models of genetic perturbations.
- Bioinformatic analysis of available data can reveal regulatory gene networks and potential transcriptional regulators.
Conclusions:
- Internet-based resources, including atlases and databases, are invaluable for modern mouse developmental biology.
- These tools enable sophisticated analysis of gene function and regulatory mechanisms during development.
- The integration of online data with genetically engineered mouse models accelerates discovery in embryogenesis research.
Related Concept Videos
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...