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Published on: April 25, 2025
Preparation of (90)YCl(3) radiopharmaceutical precursor for nuclear medicine using technology of centrifugal
J Srank1, F Melichar, A T Filyanin
1Nuclear Physics Institute of the ASCR, Public Research Institution, Radiopharmaceutical Department, 250 68 Rez near Prague, Czech Republic. srj@ujf.cas.cz
Abstract:
Separation of (90)Y from a parent solution of (90)Sr-(90)Y in 0.5 M nitric acid by two-stage liquid-liquid extraction has been investigated using centrifugal extractors. The extraction agent used was 0.25 M di-(2-ethylhexyl)phosphoric acid (D2EHPA) in n-dodecane. Back-extraction used 5 M HCl. Evaporation of HCl was performed in a rotary vacuum evaporator. Experience gained during the design, construction and running of more than 100 hot separations is presented. A short description of analytical methods used and results of the determination of chemical, radionuclidic and radiochemical purities and sterility are given.
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