Related Experiment Video
Updated: Jun 10, 2026

Robotically Delivered fMRI-Guided Personalized Transcranial Magnetic Stimulation Therapy for Treatment-Resistant Depression
Published on: April 10, 2026
Fixation, registration, and image-guided navigation using a thermoplastic facial mask in electromagnetic
Min-jie Chen1, Li-xu Gu, Wei-jie Zhang
1Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China.
Objective:
For fixation, registration, and image-guided navigation, the aim of this study was to evaluate a thermoplastic facial mask with plastic markers in achieving frameless stereotactic radiofrequency thermocoagulation (RFT).
Study Design:
A thermoplastic facial mask was remolded according to each subject's face. Six markers were placed on the surface and 6 inside. Series of 1.25-mm- and 2.5-mm-slice computerized tomography (CT) scans were made to provide radiologic data. During the phantom study, each plastic sphere inside was selected in turn as the target for frameless stereotaxy. The clinical Hartel puncture of the foramen ovale (FO) was imitated using an electromagnetic navigation system. Navigation-guided RFT was tried in 3 patients.
Results:
The mean location error was 1.29 mm (SD ± 0.39 mm). No significant difference (P > .05) was proven between 1.25-mm and 2.5-mm CT slice acquisition for the image datasets used. The FO punctures in clinical trials were successful and confirmed by CT.
Conclusions:
Registration and fixation via a fiducial marker-based thermoplastic facial mask is accurate and feasible for use in navigation-guided RFT.
