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A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
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[The effect of atrial pacing on left ventricular diastolic function and BNP levels in patients with DDD pacemaker]

Zeynep Apali1, Serdar Bayata, Murat Yeşil

  • 1Atatürk Eğitim Hastanesi, 1. Kardiyoloji Kliniği, Izmir, Türkiye.

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|August 10, 2010
PubMed

Insights

Atrial pacing in DDD pacemaker patients with normal systolic function does not negatively impact left ventricular diastolic function or NT-pro-BNP levels. This study found no significant detrimental effects from atrial pacing on these key cardiac parameters.

Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Atrial pacing is a common therapy for bradyarrhythmias.
  • The impact of atrial pacing on cardiac function, particularly diastolic function, requires further investigation.

Purpose of the Study:

  • To assess the effect of atrial pacing on left ventricular diastolic function.
  • To evaluate changes in N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels during atrial pacing.

Main Methods:

  • Prospective evaluation of 30 patients with complete atrio-ventricular block and DDD pacemakers.
  • Echocardiographic assessment of diastolic function (E/A, E'/A', E/E') and measurement of NT-pro-BNP levels during atrial sensing and pacing.
  • Statistical comparison using paired sample t-tests and Wilcoxon tests.

Main Results:

  • No significant differences were observed in echocardiographic diastolic function parameters (E/A, E'/A', E/E') between atrial sensing and pacing periods.
  • Median plasma NT-pro-BNP levels showed no significant change (p=0.86) between the two periods.
  • Left ventricular systolic function remained normal in all included patients.

Conclusions:

  • Atrial pacing in patients with DDD pacemakers and normal left ventricular systolic function does not induce additional detrimental effects on diastolic function.
  • Findings suggest that atrial pacing is safe concerning diastolic function and natriuretic peptide levels in this patient cohort.
Abstract

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