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The use of cultured amphibian thyroid glands to detect thyroid hormone disruptors

Martin van den Berg1

  • 1Institute for Risk Assessment Sciences (IRAS), Utrecht University, PO Box 80177, Utrecht 3508TD, The Netherlands. m.vandenberg@uu.nl

Toxicological Sciences : an Official Journal of the Society of Toxicology
|August 10, 2010
PubMed
Abstract

No abstract available in PubMed .

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Synthesis and Regulation of Thyroid Hormones01:20

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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