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Updated: Jun 10, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
[The protocols and the medical decision: evidences based in experience or existence?]
Severina Alice da Costa Uchôa1, Kenneth Rochel de Camargo
1Departamento de Saúde Coletiva, Universidade Federal do Rio Grande do Norte, Natal, RN, 59000-000, Brazil. aliuchoa@hotmail.com
This study explores how practical medical knowledge becomes probabilistic models, revealing how cost-benefit analyses and agent interests influence diagnostic and therapeutic decision-making in cardiology ICUs.
Area of Science:
- Science and Technology Studies (STS)
- Medical Epistemology
- Sociology of Science
Context:
- Examines the integration of practical, experience-based knowledge with formal, probabilistic models in clinical settings.
- Focuses on the consensus-building processes and criteria used for medical diagnostic and therapeutic decisions.
- Draws upon Ludwik Fleck's concept of thought collectives and the contingent nature of scientific facts.
Purpose:
- To analyze the conceptual frameworks and interests driving the transformation of practical knowledge into probabilistic epistemological models.
- To investigate the argumentation and practices involved in establishing valid knowledge criteria for clinical decision-making.
- To understand the role of external agents (government, medical-industrial complex) and internal factors (clinician skepticism) in protocol adoption.
Summary:
- Ethnographic observation of a cardiology Intensive Care Unit (ICU) in Rio de Janeiro, analyzing medical rounds and meetings.
- Utilizes Knorr-Cetina's concept of transepistemic arenas and Perelman's argumentation theory for analysis.
- Findings indicate a trend towards incorporating cost-benefit analyses and diverse agent interests into clinical protocols, alongside an ambivalent use of scientific studies and clinical experience.
Impact:
- Highlights the influence of economic and political factors on medical knowledge and practice.
- Reveals clinician ambivalence towards formal analytical tools and epidemiological thought styles.
- Suggests a gap between the theoretical underpinnings of evidence-based medicine and its practical application in complex clinical environments.
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