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GPC spin column HPLC-ESI-MS methods for screening drugs noncovalently bound to proteins

Marshall M Siegel1

  • 1Chemical and Screening Sciences Division, Wyeth Research, Pearl River, NY, USA.

Methods in Molecular Biology (Clifton, N.J.)
|August 10, 2010
PubMed

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Protein-Drug Binding: Determination Methods01:22

Protein-Drug Binding: Determination Methods

Determining protein-drug binding can be achieved through indirect and direct methods, each providing valuable insights into the interaction between proteins and drugs.
Indirect methods involve isolating the bound drug from its free form in biological samples such as blood, serum, or plasma. These techniques aim to measure the percentage of drugs bound to proteins. Equilibrium dialysis is a commonly used method where the free drug concentration at equilibrium is measured by separating the bound...